The CloneSelect by Molecular Devices (Genetix) is a cutting-edge automated system designed for high-throughput screening of cell lines and single cells. This innovative technology enables precise and efficient isolation, imaging, and dispensing of individual cells, making it an invaluable tool for various research and industrial applications.

Key features

Cytation C10 offers affordable, benchtop confocal imaging for every laboratory

• Confocal microscopy allows for enhanced image quality and analysis, unveiling a level of detail in samples that widefield optics cannot achieve

• The utilization of top-notch optical components such as the Hamamatsu sCMOS Orca camera, Semrock filters, Olympus objectives, and other reputable brands enables the capture of remarkable, high-quality images suitable for publication

• Water-immersion objectives are used to capture more light in shorter exposure times

• The Cytation C10, equipped with a combination of spinning disk confocal and widefield imaging plus multimode reader, boasts a modular, upgradable design that is versatile for various assays

• With an optional 60 µm deep sectioning disk (DSD), a clear view into thicker samples is achievable

• While widefield imaging allows for rapid acquisition of large samples at lower magnification, confocal imaging delves into small intracellular details or 3D samples, and the combined modes facilitate highly multiplexed, multiparameter imaging experiments

• Live cell imaging is facilitated by environmental controls, including incubation and CO2/O2 regulation and monitoring

• By employing imaging plus multimode detection and the hit-picking function, the microplate can be quickly prescreened with the plate reader optics, automatically imaging the samples that meet specified criteria, thereby saving time and data storage capacity

• Assay performance is enhanced by variable bandwidth, quad monochromator plate reader optics, leading to improved sensitivity and specificity

• The integration of confocal and widefield imaging with multimode detection boosts productivity, ensuring readiness for a diverse range of applications

Applications of CloneSelect

• Monoclonality Assessment:

   The CloneSelect system is widely used for assessing the monoclonality of cell lines, ensuring the reliability of research results and the consistency of cell-based assays.

• Single-Cell Cloning:

   It facilitates the isolation and cloning of single cells, allowing for the generation of monoclonal cell lines with desired characteristics.

• Cell Line Development:

   CloneSelect streamlines the process of cell line development by enabling the identification and isolation of high-producing cells for biopharmaceutical production.

• Drug Discovery:

   It plays a crucial role in drug discovery processes, particularly in the identification and isolation of rare or high-value cells for therapeutic development.

• Stem Cell Research:

   The system supports the isolation and expansion of specific stem cell populations, contributing to advancements in regenerative medicine and developmental biology.

Industries Using CloneSelect

The versatility of CloneSelect makes it an essential asset in various industries, including:

• Pharmaceutical and Biotechnology

• Academic Research Institutions

• Contract Research Organizations (CROs)

• Biomedical and Clinical Research

• Agrochemical and Food Sciences

With its advanced capabilities and broad range of applications, the CloneSelect system is revolutionizing cell-based research and development across diverse fields.

Read more at https://www.moleculardevices.com/products/clone-screening/mammalian-screening/cloneselect-imager